Myles M. Kim, PhD The LeDucq CHECKPOINT ATHERO aims to characterize the cell type specific immune checkpoint (IC) expression profiles during atherogenesis. Transcriptomics of atherosclerotic plaques helps detail mechanistic IC signaling pathways. Recently, single-cell RNA-sequencing (scRNA-seq) has become an integral … Read More

Food allergies that result in noticeable symptoms, such as hives, swelling or anaphylaxis, are relatively uncommon. However, nearly 1 in 5 adults are ‘silently’ producing IgE antibodies to food allergens without showing any overt symptoms.  Recent work by Wilson and … Read More

Graduate students Emily Dennis and Maria Muroch of the McNamara and Bekiranov labs, respectively, published their work “Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity” in the Journal Frontiers of Immunology, along with several … Read More

Team Erickson, composed of Loren Erickson, PhD, Coleen McNamara, MD (Carter Center Director, iPRIME Domain Director), and Justin Taylor, PhD tied for first place at the inaugural “Shark Tank” Competition at School of Medicine Retreat.  The competing teams submitted proposals … Read More

New research suggests sensitivity to common food allergens such as dairy and peanuts could be an important and previously unappreciated cause of heart disease, and the increased risk for cardiovascular death even includes people without obvious food allergies. UVA Health … Read More

Oom Pattarabanjird, a graduate student in the McNamara lab, reports in Nature Cardiovascular Research on her discovery of the human B cell subtype that produces antibody to target and inactivate inflammatory atherosclerotic antigens. Atherosclerosis has emerged as a chronic inflammatory … Read More

Oom Pattarabanjird (MSTP trainee with the McNamara lab) received an award for top poster at the recent Atherosclerosis Gordon Conference in Barcelona for her poster entitled “Human Marginal Zone B cells Produce Atheroprotective IgM and Confer Protection from Vascular Disease.” … Read More

iPRIME members Dr. Loren Erickson and Dr. John Lukens received an NOA supplement for their project “IgE antibody responses to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) in murine and human atherosclerosis”.  Congratulations to their team for their excellent work investigating the link between … Read More

Dr. Stefan Bekiranov, one of three PI’s of iPRIME &  Dr. Aidong Zhang, recipient of an iPRIME seed fund, have been awarded an NSF grant titled “An Explainable Machine Learning Platform for Single Cell Data Analysis” — this great work … Read More

The first iPRIME Symposium occurred on April 18th, 2023 with great success.  This program in Prominence to Preeminence, with support from the Vice President for Research at UVA showcased our successes in supporting their research. Over 60 attendees heard great … Read More