Precision health will have important societal impact in understanding health and disease at a personalized level, and transforming how medicine is practiced. iPRIME seeks to customize healthcare, with medical decisions, treatments, practices, or products being tailored to the individual patient to optimize outcomes.

There are currently many challenges to implementing precision health, including insufficient technologies, limited knowledge, and gaps in implementation. We propose to help overcome these through an interdisciplinary approach, leveraging strengths at UVA. We focus this initial effort on cardiovascular disease (CVD) to achieve rapid and sustained preeminence in the area of immunomedicine for CVD. Yet, our platform can clearly be expanded going forward to include other fields of precision health.

Dr. Antonio Abbate Joins the University of Virginia School of Medicine Cardiovascular Research Center
Dr. Antonio Abbate Joins the University of Virginia School of Medicine Cardiovascular Research Center

We are excited to welcome Dr. Antonio Abbate to the University of Virginia School of medicine Cardiovascular Research Center.  Dr. Abbate is one of the world’s leading experts in precision Immunomedicine.  Welcome to UVA, Dr. Abbate! Dr. Antonio Abbate joined … Read More

iPRIME Investigators partnered with colleagues from the La Jolla Institute (LJI) for a collaborative project resulting in a publication in “Frontiers of Cardiovascular Medicine”
iPRIME Investigators partnered with colleagues from the La Jolla Institute (LJI) for a collaborative project resulting in a publication in “Frontiers of Cardiovascular Medicine”

iPRIME Investigators have partnered with colleagues from the La Jolla Institute (LJI) to utilize single cell multi-omic analysis of human circulating immune cells to identify the B cell subtype in humans that is associated with IgE sensitization to alpha gal … Read More

Dr. Loren Erickson and Dr. Coleen McNamara receive NIH R01 to study the role of IgE and alpha gal in Coronary Artery Disease
Dr. Loren Erickson and Dr. Coleen McNamara receive NIH R01 to study the role of IgE and alpha gal in Coronary Artery Disease

The research project seeks to understand the effects of IgE to alpha-gal on atherosclerotic plaque development and define immune mechanisms mediating IgE sensitization to alpha-gal linked to atherosclerotic cardiovascular disease in mice and humans. As part of the iPRIME initiative, … Read More

Commonwealth Health Review Board awards Dr. Mike Brown funds to study the role of GITR and Ox40 in patients with cardiovascular disease
Commonwealth Health Review Board awards Dr. Mike Brown funds to study the role of GITR and Ox40 in patients with cardiovascular disease

Dr. Mike Brown of the Carter Immunology Center received $252,434 for his project “Risky variants in human cardiovascular disease” to study the role of Glucocorticoid-induced TNFR-related protein (GITR), an immune modulator of inflammation and Ox40, a T-cell receptor, and their … Read More


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